Paclitaxel dosing and growth factors in breast cancer



However, substantial differences in the toxicity profiles favor weekly administration. Although synthesis of paclitaxel and its analogue, docetaxel, first began in the late s and early s [ 34 ], clinical development of the taxanes for breast cancer treatment paclitaxel dosing and growth factors in breast cancer in the s, when the antitumor activity of single-agent regimens in patients with advanced disease began to be documented in phase II trials [ 56 ]. Only one grade 3—4 hematologic toxicity leukopenia occurred in the weekly group [ 54 ]. Chemotherapy was given on days 1, 8, and 15 of a day cycle.



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Paclitaxel dosing and growth factors in breast cancer
Paclitaxel dosing and growth factors in breast cancer
Paclitaxel dosing and growth factors in breast cancer
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Weekly Administration of Docetaxel and Paclitaxel in Metastatic or Advanced Breast Cancer

Breast Cancer Res Treat ; Hematologic and nonhematologic toxicities occurred less frequently with weekly therapy. Docetaxel and gemcitabine inanthracycline-resistant advanced breast cancer: An estimatedwomen will be diagnosed with breast cancer in the U.

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Paclitaxel dosing and growth factors in breast cancer

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Myeloid growth factor support for dose-dense adjuvant chemotherapy for breast cancer.

Anti-cancer Res ; All patients receiving paclitaxel should be pretreated with corticosteroids, diphenhydramine, and H 2 -receptor antagonists to prevent hypersensitivity reactions [ 16 ]. When paclitaxel is administered in a dose-dense fashion without growth factor support brief treatment delays are common.

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