However, substantial differences in the toxicity profiles favor weekly administration. Although synthesis of paclitaxel and its analogue, docetaxel, first began in the late s and early s [ 34 ], clinical development of the taxanes for breast cancer treatment paclitaxel dosing and growth factors in breast cancer in the s, when the antitumor activity of single-agent regimens in patients with advanced disease began to be documented in phase II trials [ 56 ]. Only one grade 3—4 hematologic toxicity leukopenia occurred in the weekly group [ 54 ]. Chemotherapy was given on days 1, 8, and 15 of a day cycle.
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Weekly Administration of Docetaxel and Paclitaxel in Metastatic or Advanced Breast Cancer
Breast Cancer Res Treat ; Hematologic and nonhematologic toxicities occurred less frequently with weekly therapy. Docetaxel and gemcitabine inanthracycline-resistant advanced breast cancer: An estimatedwomen will be diagnosed with breast cancer in the U.
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Myeloid growth factor support for dose-dense adjuvant chemotherapy for breast cancer.
Anti-cancer Res ; All patients receiving paclitaxel should be pretreated with corticosteroids, diphenhydramine, and H 2 -receptor antagonists to prevent hypersensitivity reactions [ 16 ]. When paclitaxel is administered in a dose-dense fashion without growth factor support brief treatment delays are common.